Esther van Andel, WUR

Title: Romantic Surfaces – Towards Sensitive and Selective Antifouling Biosensor Platforms
Session: 15:15


False outcomes of diagnostic tests are a major concern in medical health care. In order to perform more reliable tests it is of crucial importance to diminish background signals that arise from the non-specific binding of biomolecules. So-called romantic surfaces can solve this problem as they will repel all biomolecules except that special one you are interested in. To achieve this, repellent, antifouling layers need to be introduced between the sensor surface and its recognition elements (e.g. antibodies). In this contribution the use of zwitterionic polymer brushes as highly antifouling layers will be demonstrated. To this end, newly designed and synthesized zwitterionic monomers were used for controlled surface-initiated polymerizations, yielding improved polymer brushes regarding their antifouling properties and subsequent functionalizability. The polymer-coated surfaces were fully characterized using XPS, contact angle measurements, IRRAS and XRR, while their antifouling properties were evaluated using several sensing techniques like reflectometry and surface plasmon resonance (SPR).


to be announced

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