Digvijay Gahtory, WUR

Title: Can nanochemistry provide a quick and reliable method for detection of drug resistant malaria?
Session: 11:00


In this project we aim to develop a novel biosensor based on surface-immobilised forced-intercalation peptide nucleic acids (FIT-PNAs) for the detection of DNA of the malaria parasite P. falciparum. Single nucleotide polymorphisms in the P. falciparum genome are a major concern due to emergence of drug-resistant malaria. Current technologies for detection of such SNPs are not adequate in terms of sensitivity and cost. FIT-PNA based sensors provide an interesting approach for SNP detection due to their ability to selectively signal match/mismatch upon hybridisation with DNA/RNA. This project aims at surface immobilisation of FIT-PNAs using different chemical strategies and their evaluation as SNP sensors. These sensors can offer several advantages over current detection techniques such as ease of use, reusability and sensitive detection of point mutations.


to be announced

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