Anja van de Stolpe, Philips

Title: In vitro human organ and disease culture models: towards in vitro (pre-)clinical trials “on chips”
Session: 10:10

Abstract

Development of targeted therapy for personalized treatment of patients requires understanding of the human physiology and pathophysiology. Animal disease models are not sufficiently representative for healthy and diseased human tissues. Reasons are the underlying human genetics, and the involvement of the immune response in manifestation, evolution and treatment response of every disease. Within the hDMT (human organ and Disease Model technologies) human healthy organ and disease organ-on-chip models will be developed for use by both academic institutions and pharma, cosmetics, food and medical device companies. Types of models range from relatively simple suited for high throughput drug screening use to complex models suited for use as "clinical trial on-chip". To make this effort successful, it is important to involve medical experts in the program, validate models by comparing with in vivo (patho)physiology, define relevant readouts for cell function, and make organ-on-chip devices available as culture disposables.

Bio

Dr. Anja van de Stolpe is Medical Scientific Advisor and Research Fellow (Senior Director level) at Philips Research. She is by background a registered clinical internist specialized in hematology with 10 years of experience in clinical internal medicine and hemato-oncology / blood coagulation in academic and peripheral hospital settings. A current research interest is innovative molecular diagnostics, especially related to oncology.

She is scientifically involved in multiple translational research projects within Philips Research, ranging from circulating tumour cells to sequencing and array-based diagnostics, and oncogenic pathway modelling. She is also actively involved in Business Development, for which she received the Philips Research Entrepreneurs Award. She is cofounder and member of the Scientific Advisory Board of the stem cell company Pluriomics; and a co-founder of the European School for Science Education (ESSE) for post-academic education of medical specialists.

As a postdoc she spent two years at Stanford University (nephrology research), followed by a faculty position in Rochester School of Dentistry and Medicine. She was registered as clinical internist in 1989, specialized in hematology/coagulation at the Academic Hospital Nijmegen, and acquired extensive skills in cell (intracellular signalling) and molecular biology (transcription regulation), and stem cell technology (HESC), at the Hubrecht Institute in Utrecht, where she obtained her PhD degree in 1996. She joined Philips in 2006.

She has over 20 publications in peer reviewed journals, including Am. J. Phys. and J. Cell Biology, received several awards and is co-author of two books on stem cells and stem cell technologies.

 

 

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